Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
نویسندگان
چکیده
منابع مشابه
Heterologous Expression, Purification and Immunoreactivity of the Antigen 5 from Polybia paulista Wasp Venom
Polybia paulista (Hymenoptera: Vespidae) is responsible for a high number of sting accidents and anaphylaxis events in Southeast Brazil, Argentina and Paraguay. The specific detection of allergy to the venom of this wasp is often hampered by the lack of recombinant allergens currently available for molecular diagnosis. Antigen 5 (~23 kDa) from P. paulista venom (Poly p 5) is a highly abundant a...
متن کاملRenal- and calcium-dependent vascular effects of Polybia paulista wasp venom
In the present study, the effects of Polybia paulista venom (PPV) on renal and vascular tissues were investigated. Isolated kidneys perfused with PPV (1 and 3 μg/mL) had increased perfusion pressure, renal vascular resistance, urinary flow, and glomerular filtration rate; and reduced sodium tubular transport. Histological evaluation demonstrated deposits of proteins in Bowman’s space and tubula...
متن کاملCytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic effects of the venom of the wasp Polybia paulista.
Hymenoptera venoms are constituted by a complex mixture of chemically or pharmacologically bioactive agents, such as phospholipases, hyaluronidases and mastoparans. Venoms can also contain substances that are able to inhibit and/or diminish the genotoxic or mutagenic action of other compounds that are capable of promoting damages in the genetic material. Thus, the present study aimed to assess ...
متن کاملHyaluronidase from the venom of the social wasp Polybia paulista (Hymenoptera, Vespidae): Cloning, structural modeling, purification, and immunological analysis.
In this study, we describe the cDNA cloning, sequencing, and 3-D structure of the allergen hyaluronidase from Polybia paulista venom (Pp-Hyal). Using a proteomic approach, the native form of Pp-Hyal was purified to homogeneity and used to produce a Pp-specific polyclonal antibody. The results revealed that Pp-Hyal can be classified as a glycosyl hydrolase and that the full-length Pp-Hyal cDNA (...
متن کامل93 Purification of the Allergenic Protein Hyaluronidase From the Venom of Social Wasp Polybia Paulista (Hymenoptera: Vespidae)
93 Purification of the Allergenic Protein Hyaluronidase From the Venom of SocialWasp Polybia Paulista (Hymenoptera: Vespidae) Débora Laís Justo Jacomini, MD, Franco Dani Campos Pereira, 1 José Roberto Aparecido dos Santos Pinto, MD, Lucilene Delazari dos Santos, PhD, Anally Ribeiro da Silva Menegasso, Mário Sérgio Palma, PhD, Ricardo de Lima Zollner, PhD, and Márcia Regina BrochettoBraga, PhD. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicon
سال: 2017
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2017.08.002